Custom Peptides
Cayman Chemical 1PalmItoyl2Stearoyl3Buty 10mg
A triacylglycerol; has been used to determine the stereospecificity and typoselectivity of lipases
Cayman Chemical KInsenosIde 10mg
A glycoside with diverse biological activities; increases adipose triglyceride lipase-mediated lipolysis and hydrolysis of triglycerides in C3H10T1/2 adipocytes; increases phosphorylation of PPARα and CREB in adipocytes in vitro; decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with CIA; decreases the expression of IL-1β, TNF-α, and MMP-9 and increases the expression of IL-10 in inflamed joints of mice with CIA at 300 mg/kg
Cayman Chemical CystamIn-d8hydrochlorIde 10mg
An internal standard for the quantification of cystamine by GC- or LC-MS
Cayman Chemical ColumbInadIn 10mg
A coumarin with diverse biological activities; inhibits depolarization-induced calcium uptake in GH3 rat pituitary cells; inhibits HIV-1 replication in H9 cells (EC50 = 4.6 µM); inhibits IL-1β-induced production of IL-6 in A549 cells and reduces iNOS levels and LPS-induced NO production in MH-S cells; decreases the number of alveolar and interstitial macrophages and alveolar wall thickness in a mouse model of LPS-induced lung inflammation from 20-60 mg/kg; reduces formalin-induced paw licking in mice at 10 mg/kg
Cayman Chemical PIclamIlast 10mg
A PDE4 inhibitor (IC50 = 0.31 nM); selective for PDE4 over PDE1, PDE2, PDE3, PDE5, and PDE7A in cell-free assays (IC50s = >100, 40, >100, 14, and >10 μM, respectively); inhibits superoxide production by guinea pig eosinophils and histamine-induced contraction in isolated guinea pig trachea (IC50s = 24 and 2 nM, respectively); inhibits eosinophil, neutrophil, lymphocyte, and TNF-α accumulation in bronchoalveolar lavage fluid (BALF) from ovalbumin-sensitized rats (ED50s = 23.8, 14.1, 19.5, and 14.4 μmol/kg, respectively); nhibits eosinophil, neutrophil, lymphocyte, and TNF-α accumulation in BALF from ovalbumin-sensitized rats (ED50s = 23.8, 14.1, 19.5, and 14.4 μmol/kg, respectively); inhibits ovalbumin-induced bronchoconstriction in a guinea pig model of asthma (ED50 = 0.033 mg/kg)
Cayman Chemical SCIADOPITYSIN 10MG
A biflavonoid with diverse biological activities; reduces Aβ42-induced cytotoxicity in PC12 cells (EC50 = 9.84 μM); decreases methylglyoxal-induced insulin secretion, production of ROS, cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells from 0.1-10 μM; inhibits P-gp (IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells; inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss
Cayman Chemical LevonrdefrIn 10mg
A vasoconstrictor; (–)-enantiomer of nordefrin; rapidly increases blood pressure and heart rate in anesthetized dogs (1-5 UG/kg); in combination with mepivacaine, increases systolic arterial blood pressure in anesthetized dogs (0.514 and 1.542 mg/kg)
Cayman Chemical LIrafugratInIb 10mg
A covalent FGFR2 inhibitor (IC50 = 0.003 µM); selective for FGFR2 over FGFR1, -3, and -4 (IC50s = 0.77, 0.26, and 15 µM, respectively); inhibits the proliferation of SNU-16 cells (IC50 = 0.002 µM); reduces intratumoral FGFR2 phosphorylation and tumor volume in an FGFR2-amplified SNU-16 gastric cancer mouse xenograft model at 10 mg/kg
Cayman Chemical DPhe7aMSHtrIfluoroacet 10mg
A peptide derivative of α-MSH and a synthetic intermediate
Cayman Chemical ProstaglndIn E1 Alcohol 10mg
A non-irritant bronchodilator with relaxant activity on human bronchial muscle; binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively
Cayman Chemical IsoquercItrosIde 10mg
A 3-O-glucoside of quercetin that displays antioxidant and chemoprotective effects both in vitro and in vivo.
Cayman Chemical nsamItocIn P-3 10mg
A microtubule depolymerizing agent that binds tubulin (Kd = 1.3 µM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation
Cayman Chemical LnInamIvIr octnoate 10mg
An inhibitor of influenza neuraminidases and a prodrug form of laninamivir; selectively inhibits the neuraminidases from influenza A H1N1, H2N2, and H3N2 strains (mean IC50s = 822, 128, and 114 nM, respectively) over the neuraminidases from influenza B Victoria and Yamagata strains (mean IC50s = >10,000 nM for both); increases survival in a mouse model of lethal influenza H1N1 infection when administered intranasally at 0.95 UG/kg